Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages . Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells . Required for efficient T-lymphocyte and neutrophil migration . Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin . Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis . In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF . .

Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1),NCKAP1L HEM1

P55160

3071

Human,Rat,Mouse

WB

WB 1:500-2000

This antibody detects endogenous levels of human NCKPL

124kDa

Rabbit

Synthesized peptide derived from human NCKPL.

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.