Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini . May have a general role in telomere regulation . Promotes in vitro the ability of TERT to elongate telomeres . Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization . Binds to the single-stranded 5''-(GTGTGG)(4)GTGT-3'' telomeric DNA, but not to a telomerase RNA template component (TER) . .; Plays a role in nonsense-mediated mRNA decay . Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation . Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA . .

Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a),SMG6 C17orf31 EST1A KIAA0732

Q86US8,P61406

23293/103677/103677

Human,Mouse

WB

WB 1:500-2000

This antibody detects endogenous levels of human EST1A

156kDa

Rabbit

Synthesized peptide derived from human EST1A AA range: 688-738

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.