Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma . Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy . Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation . However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production . Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation . Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization . .

Pyrin (Marenostrin),MEFV MEF TRIM20

O15553,Q9JJ26,Q9JJ25

4210/54483/54483

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of human MEFV

86kDa

Rabbit

Synthesized peptide derived from human MEFV AA range: 517-567

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.