K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an ''ion flux gating'' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent ''leak'' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids . Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties . In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) . .

Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit),KCNK10 TREK2

P57789,Q9JIS4

54207

Human,Rat,Mouse

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:50-300
IF 1:50-200
ICC 1:50-200

KCNK10(TREK-2) protein(A237) detects endogenous levels of KCNK10(TREK-2)

59kDa

Rabbit

Synthetic Peptide of KCNK10 (TREK-2).

Polyclonal

Rabbit,IgG

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.