13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Binds the telomeric double-stranded 5''-TTAGGG-3'' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes . In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo . Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection . Shelterin associates with arrays of double-stranded 5''-TTAGGG-3'' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways . Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3'' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair . Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo . Preferentially binds to positive supercoiled DNA . Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology . Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). .
Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein),TERF2 TRBF2 TRF2
Q15554,O35144
7014/21750
Human,Mouse,Rat
WB
WB 1:500-2000
This antibody detects endogenous levels of TRF2 (Phospho-Thr188) at Human, Mouse,Rat
55kDa
Rabbit
Polyclonal
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
1 mg/ml
Store at -20℃. Stable for 12 months from date of receipt.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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