Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities . Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 . Plays an important role in double-strand breaks (DSBs) repair following DNA damage . Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) . Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A . May play a role in a signaling pathway regulating nuclear functions of cell proliferation . Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at ''Thr-434'' (By similarity). .

Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB),DYRK1A DYRK MNB MNBH

Q13627,Q61214,Q63470

1859/13548/25255

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of DYRK1A/B at Human, Mouse,Rat

84kDa

Rabbit

Polyclonal

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.