RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function . Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II . The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) . LARP7 specifically binds to the highly conserved 3''-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex . LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing . Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2''-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes . U6 snRNA 2''-O-methylation is required for mRNA splicing fidelity . Binds U6 snRNAs with a 5''-CAGGG-3'' sequence motif . U6 snRNA processing is required for spermatogenesis (By similarity). .

La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S),LARP7 HDCMA18P

Q4G0J3,Q05CL8,Q5XI01

51574/28036/686883

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of LARP7 at Human, Mouse,Rat

64kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.