E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy . Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for ''Lys-63''-linked ubiquitination which promotes the interaction of STING1 with TBK1 . Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages . Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner . Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions . Ubiquitinates XIAP and targets it for proteasomal degradation . Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation . May ubiquitinate BBS2 . Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored ''Lys-63''-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation . Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL . Under metabolic stress and phosphorylation by CHK2, mediates ''Lys-63''-linked ubiquitination of ATG7 at ''Lys-45'' to initiate autophagy . .; (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo . Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo . .

E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A),TRIM32 HT2A

Q13049,Q8CH72

22954/69807

Human,Mouse

WB

WB 1:500-2000

This antibody detects endogenous levels of TRIM32 at Human, Mouse

72kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.