Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination . Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3''-triiodothyronine (T3), 3,3'',5''-triiodothyronine (rT3) to 3,3''-diiodothyronine (3,3''-T2) and 3'',5''-diiodothyronine (3'',5''-T2) to 3''-monoiodothyronine (3''-T1) via outer-ring deiodination (ORD) . Catalyzes the deiodination of T4 to 3,3'',5''-triiodothyronine (rT3) via inner-ring deiodination (IRD) . Catalyzes the deiodination of T3 to 3,3''-T2, 3,5-diiodothyronine (3,5-T2) to 3- monoiodothyronine (3-T1) and 3,3''-T2 to 3-T1 via IRD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3'',5''-triiodothyronamine and 3'',5''-diiodothyronamine . Catalyzes the phenolic ring deiodination of 3,3''-diiodothyronamine and tyrosyl ring deiodinations of 3,5,3''-triiodothyronamine and 3,5-diiodothyronamine (By similarity). Catalyzes the deiodination of L-thyroxine sulfate and 3,3'',5-triiodo-L-thyronine sulfate via IRD and of 3,3'',5''-triiodo-L-thyronine sulfate via ORD (By similarity). .

Type I iodothyronine deiodinase (EC 1.21.99.3) (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5''-deiodinase),DIO1 ITDI1 TXDI1

P49895,Q61153,P24389

1733/13370/25430

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of DIO1 at Human, Mouse,Rat

27kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.