Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel . Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER . May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport . Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane . Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane . Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome . .; (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells. .

Translocating chain-associated membrane protein 1 (Protein TRAM1),TRAM1 TRAM

Q15629,Q91V04,Q5XI41

23471/72265/312903

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of TRAM1 at Human, Mouse,Rat

41kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.