Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery . Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex . Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits . Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 . Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 . .; [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. .

Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17),ITSN1 ITSN SH3D1A

Q15811,Q9Z0R4,Q9WVE9

6453/16443/29491

Human,Mouse,Rat

WB

WB 1:500-2000

This antibody detects endogenous levels of Intersectin 1 at Human, Mouse,Rat

189kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.