Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3'' poly(A) tail creating a heterogeneous 3'' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation . Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn''t need a cofactor for polyadenylation activity (in vitro) . Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 . Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion . Mediates 3'' adenylation of the microRNA MIR21 followed by its 3''-to-5'' trimming by the exoribonuclease PARN leading to degradation . Mediates 3'' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3''-to-5'' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation . .

Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2),TENT4B GLD4 PAPD5 TRF4-2 TUT3

Q8NDF8,Q68ED3

64282/214627

Human,Mouse

WB

WB 1:500-2000

This antibody detects endogenous levels of PAPD5 at Human, Mouse

63kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.