E3 ubiquitin-protein ligase that specifically mediates the formation of ''Lys-6''-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage . It is unclear whether it also mediates the formation of other types of polyubiquitin chains . The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability . Regulates centrosomal microtubule nucleation . Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle . Required for FANCD2 targeting to sites of DNA damage . Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation . Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks . Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 . Acts as a transcriptional activator . .

Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1),BRCA1 RNF53

P38398,P48754,O54952

672/12189/497672

Human,Mouse,Rat

WB,IHC

WB 1:500-2000
IHC 1:50-200

This antibody detects endogenous levels of BRCA1 (Phospho Ser1497) Rabbit pAb at Human, Mouse,Rat

205kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.