ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation . Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux . Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules . In microglia, may mediate NADPH transport across the plasma membrane . In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-1 . Cooperates with KCNK6 to activate NLRP3 inflammasome (By similarity). Activates death pathways leading to apoptosis and autophagy . Activates death pathways leading to pyroptosis (By similarity). .; [Isoform B]: Shows ion channel activity but no macropore function. .; [Isoform H]: Non-functional channel. .; [Isoform J]: Non-functional channel. .

P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor),P2RX7

Q99572,Q9Z1M0,Q64663

5027/18439/29665

Human,Mouse,Rat

WB,IHC

WB 1:500-2000
IHC 1:50-200

This antibody detects endogenous levels of P2RX7 at Human, Mouse,Rat

65kDa

Rabbit

Polyclonal

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1 mg/ml

Store at -20℃. Stable for 12 months from date of receipt.