Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis . Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) . Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction . Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) . Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias . Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization . .

Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5''-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)],ATIC PURH OK/SW-cl.86

Human,Mouse,Rat

WB,IP

WB 1:1000-5000
IP 1:50-1:100

65kDa

Rabbit

Recombinant protein of human ATIC

Monoclonal

U310

IgG

Affinity Purification

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% New type preservative N and 0.05% BSA.

Store at -20℃. Stable for 12 months from date of receipt.