Receptor for glucocorticoids (GC) . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors . Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling . Plays a role in rapid mRNA degradation by binding to the 5'' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). .; [Isoform Alpha]: Has transcriptional activation and repression activity . Mediates glucocorticoid-induced apoptosis . Promotes accurate chromosome segregation during mitosis . May act as a tumor suppressor . May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). .; [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha . Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed . Loses this transcription modulator function on its own . Has no hormone-binding activity . May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner . Directly regulates STAT1 expression in isoform Alpha-independent manner . .; [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism .; [Isoform GR-P]: Increases activity of isoform Alpha. .; [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. .; [Isoform 10]: Has transcriptional activation activity. .; [Isoform Alpha-C1]: Has transcriptional activation activity. .; [Isoform Alpha-C2]: Has transcriptional activation activity. .; [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity . Mediates glucocorticoid-induced apoptosis . .; [Isoform Alpha-D1]: Has transcriptional activation activity. .; [Isoform Alpha-D2]: Has transcriptional activation activity. .; [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation . Has transcriptional repression activity . .

Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1),NR3C1 GRL

P04150

2908

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:1000-1:5000
IHC 1:100-400
IF 1:100-1:400
ICC 1:100-1:400
ELISA 1:5000-1:20000

94kDa

Rabbit

Monoclonal

O271

Monoclonal, rabbit, IgG, Kappa

Protein A

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Store at -20℃. Stable for 12 months from date of receipt.