Bone protein that constitutes 1-2% of the total bone protein, and which acts as a negative regulator of bone formation . Functions to limit bone formation without impairing bone resorption or mineralization (By similarity). It binds strongly to apatite and calcium . .; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development. .

Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein),BGLAP

P02818,P86546,P04640

632

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:100-1:500
IHC 1:100-400
IF 1:100-1:400
ICC 1:100-1:400
ELISA 1:5000-1:20000

Endogenous

22kDa

Rabbit

Monoclonal

J201

IgG,Kappa

Protein A

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Store at -20℃. Stable for 12 months from date of receipt.