Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton . Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement . These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction . The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs . Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation . .

Moesin (Membrane-organizing extension spike protein),MSN

P26038;P35241;P15311,O35763;P31977

4478;5962/17698;19684;22350/81521;54319

Human,Mouse,Rat

WB,IHC,IF,ICC,IP,ELISA

WB 1:1000-1:5000
IHC 1:100-400
IF 1:100-1:400
ICC 1:100-1:400
IP 1:50-1:200
ELISA 1:5000-1:20000

Ezrin/Radixin/Moesin (Phospho Thr567/Thr564/Thr558) Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein only when phosphorylated at Thr567/Thr564/Thr558.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YKtLR

65kDa

Rabbit

Monoclonal

P145

IgG,Kappa

Protein A

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Store at -20℃. Stable for 12 months from date of receipt.