A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins . Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma . .; [Isoform 2]: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling . In addition to its tyrosine phosphatase activity has ecto-5''-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity). .; [PAPf39]: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection . SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea . Target cell attachment and enhancement of HIV infection is inhibited by surfen . Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection . .

p15309

Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5''-nucleotidase) (5''-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5''-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39],ACP3 ACPP,Prostatic acid phosphatase,Thiamine monophosphatase,ACPP,TMPase,ACP3,Protein tyrosine phosphatase ACP3,5''-nucleotidase,Acid phosphatase 3,PAP,5''-NT,Ecto-5''-nucleotidase

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

45kD

Rabbit

Recombinant Human ACP3 (Leu167-Thr335).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.