Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation . Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex . This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity . Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) . Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK . .

o95999

B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10),BCL10 CIPER CLAP,CED-3/ICH-1 prodomain homologous E10-like regulator, CLAP, B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, Cellular homolog of vCARMEN, cCARMEN, CIPER, Bcl-10, hCLAP, Cellular-E10, CARD-like apoptotic protein, c-E10, Mammalian CARD-containing adapter molecule E10, B-cell lymphoma/leukemia 10, mE10

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

27kD

Rabbit

Recombinant Human BCL10 (Met1-Gln233).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.