Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation . Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC . Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner . Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion . In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM . May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation . When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 . Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 . Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline . .; (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. .

p27487

Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)],DPP4 ADCP2 CD26,TP103,Dipeptidyl peptidase IV,ADABP,Dipeptidyl peptidase 4,CD26,DPP4,Dipeptidyl peptidase IV soluble form,Dipeptidyl peptidase IV membrane form,DPP IV,ADCP2,Adenosine deaminase complexing protein 2,ADCP-2,T-cell activation antigen CD26

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

89kD

Rabbit

Recombinant Human CD26/DPP4 (Thr401-Thr746).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.