Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades . The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state . Signaling by an activated GPCR promotes GDP release and GTP binding . The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal . Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) . Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) . Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens. .

p29992

Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha),GNA11 GA11,G-protein subunit alpha-11,Guanine nucleotide-binding protein G(y) subunit alpha,GNA11,G alpha-11,GA11,Guanine nucleotide-binding protein subunit alpha-11

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

43kD

Rabbit

Recombinant Human GNA11 (Met1-Val359).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.