Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase . ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity . May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo . Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity . Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 . Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes . Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation . .

q86y34

Adhesion G protein-coupled receptor G3 (G-protein coupled receptor 97) [Cleaved into: Adhesion G-protein coupled receptor G3, N-terminal fragment (ADGRG3 N-terminal fragment); Adhesion G-protein coupled receptor G3, C-terminal fragment (ADGRG3 C-terminal fragment)],ADGRG3 GPR97 PGR26,ADGRG3, PGR26, G-protein coupled receptor 97, Adhesion G protein-coupled receptor G3, GPR97, G-protein coupled receptor PGR26

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

61kD

Rabbit

Recombinant Human ADGRG3 (Gln21-Ser272).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.