Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 . Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets . Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells . .

q9y5z0

Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase),BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852,Aspartyl protease 1, Membrane-associated aspartic protease 1, Beta-secretase 2, ASP21, BACE2, Asp 1, ALP56, Beta-site APP cleaving enzyme 2, Aspartic-like protease 56 kDa, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Theta-secretase, Memapsin-1, AEPLC, ASP1, DRAP

Human

ELISA,SPR

ELISA 1:5000-1:20000
SPR,The optimal dilutions should be determined by the end user.

57kD

Alpaca

Monoclonal

SA431

VHH-8His-Cys-tag

Purified by Nickel column.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.