Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis . Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity . Also plays an important role in NK-cells cytotoxicity . Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule . In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content . Presents carbohydrate ligands to selectins . .; (Microbial infection) Acts as a receptor for Lassa virus glycoprotein . Also promotes fusion of the virus with host membrane in less acidic endosomes . .; (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. .

p11279

Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a),LAMP1,LAMP1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP-1, Lysosome-associated membrane glycoprotein 1

Human

FC

FC 1:50-1:200

45kD

Mouse

Monoclonal

Ma247

IgG1, kappa

Protein A/G purified from cell culture supernatant.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

0.88 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.