Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal . Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis . The interaction with membrane-bound IL6R and IL6ST stimulates ''classic signaling'', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates ''trans-signaling''. Alternatively, ''cluster signaling'' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). .; [Isoform 1]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through ''cluster signaling'' by dendritic cells (By similarity). .; [Isoform 2]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity . The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 ''trans-signaling''. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases . In complex with IL6, is required for induction of VEGF production . Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). ''Trans-signaling'' in central nervous system regulates energy and glucose homeostasis (By similarity). .; [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity . The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 ''trans-signaling''. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases . In complex with IL6, is required for induction of VEGF production . Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). ''Trans-signaling'' in central nervous system regulates energy and glucose homeostasis (By similarity). .

P08887

Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)],IL6R,sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha

Human

FC

FC 1:50-1:200

52kD

PE

Mouse

Monoclonal

SA294

IgG1, kappa

0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

0.5 mg/ml

Store at 4℃ for 12 months. Protect from light. Do not freeze.