Tyrosine kinase involved in the regulation of tissues remodeling . It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. .

q16832

Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b),DDR2 NTRKR3 TKT TYRO10,Discoidin domain-containing receptor 2, Discoidin domain receptor 2, Tyrosine-protein kinase TYRO10, TKT, TYRO10, CD167b, Discoidin domain-containing receptor tyrosine kinase 2, Receptor protein-tyrosine kinase TKT, DDR2, Neurotrophic tyrosine kinase, receptor-related 3, NTRKR3, CD167 antigen-like family member B

Human

ELISA

ELISA 1:5000-1:20000

97kD

Alpaca

Monoclonal

SA224

VHH-8His-Cys-tag

Purified by Nickel column.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.