MJJ163446

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MJJ163446S 50ug
MJJ163446M 100ug
MJJ163446L 1000ug

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

ABMART实验方案下载

   蛋白质免疫共沉淀

   蛋白质印迹

   免疫荧光

   免疫组化

   膜再生

   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

经典一抗-Human CD288/TLR8/PRO286 Antibody(SA206)

Datasheet

Background

Description

Endosomal receptor that plays a key role in innate and adaptive immunity . Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 . Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses . Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction . In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively . .

Uniprot

q9nr97

Alternative Names

Toll-like receptor 8 (CD antigen CD288),TLR8 UNQ249/PRO286,Toll-like receptor 8, CD288, TLR8

Specificity

Application Image

Reactivity

Human

Application

ELISA

Recommended Dilution

ELISA 1:5000-1:20000

Mol weight

120kD

Conjugation

Source

Mouse

Immunogen

Clonality

Monoclonal

Clone No.

SA206

Isotype

IgG2a, kappa

Purification

Protein A/G purified from cell culture supernatant.

Purity

>95% as determined by SDS-PAGE.

Buffer

0.01M PBS, pH 7.4.

Concentration

1 mg/ml

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.

Note

艾比玛特医药科技(上海)有限公司
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技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
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徐经理:手机15618191473(微信同号)
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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

46c73bc4c7a4d51a3ce472aedb80205b_compress.jpg

      微信客服

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