Acts as an inhibitory receptor for myeloid cells and mast cells . Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands . May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 . Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). .

q8tdq1

CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f),CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111,IREM1, Immunoglobulin superfamily member 13, NK inhibitory receptor, CD300 antigen-like family member F, CD300F, CD300LF, CLM-1, IGSF13, NKIR, IREM-1, Immune receptor expressed on myeloid cells 1, CMRF35-like molecule 1, CD300f, IgSF13, CLM1

Human

ELISA

ELISA 1:5000-1:20000

33kD

Mouse

Monoclonal

SA854

IgG2a, kappa

Protein A/G purified from cell culture supernatant.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.