HJJ975365

货号 规格 价格(¥)
HJJ975365S 50ul
HJJ975365M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

经典一抗-Human CD80/B7-1 Antibody(SA453)

Datasheet

Background

Description

Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation . Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells . In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines . In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway . Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses . Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity). .; (Microbial infection) Acts as a receptor for adenovirus subgroup B. .

Uniprot

p33681

Alternative Names

T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80),CD80 CD28LG CD28LG1 LAB7,CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1

Specificity

Application Image

Reactivity

Human

Application

FC,ELISA

Recommended Dilution

FC 1:50-1:200
ELISA 1:5000-1:20000

Mol weight

34kD

Conjugation

Source

Human

Immunogen

Clonality

Monoclonal

Clone No.

SA453

Isotype

IgG1, kappa

Purification

Protein A/G purified from cell culture supernatant.

Purity

>95% as determined by SDS-PAGE.

Buffer

0.01M PBS, pH 7.4, 0.09% Sodium azide.

Concentration

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.

Note

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技术支持:15618194176(微信同号)

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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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