Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 . The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis . Regulates leukocyte adhesion and migration processes at the endothelium . Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner . In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins . In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 . .; [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. .; [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. .; (Microbial infection) Mediates the cytoadherence of erythrocytes infected with parasite P.falciparum (strain 3D7) with endothelial cells by interacting with P.falciparum CBP1 and CBP2 expressed at the surface of erythrocytes . The adhesion prevents the elimination of infected erythrocytes by the spleen (Probable). .

P78423

Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine],CX3CL1 FKN NTT SCYD1 A-152E5.2,Small-inducible cytokine D1, Fractalkine, Neurotactin, C-X3-C motif chemokine 1, NTT, CX3CL1, SCYD1, FKN, CX3C membrane-anchored chemokine

Human

FC,ELISA

FC 1:50-1:200
ELISA 1:5000-1:20000

43kD

APC

Mouse

Monoclonal

SA715

IgG2a, kappa

0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

0.5 mg/ml

Store at 4℃ for 12 months. Protect from light. Do not freeze.