A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion . Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes . Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells . Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 . Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier . .

q14126

Desmoglein-2 (Cadherin family member 5) (HDGC),DSG2 CDHF5,CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5

Human

WB,FC,ELISA,Blocking

WB 1:500-1:2000
FC 1:50-1:200
ELISA 1:5000-1:20000
Blocking,The optimal dilutions should be determined by the end user.

123kD

Mouse

Monoclonal

D279

IgG2a, kappa

Protein A/G purified from cell culture supernatant.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4, 0.09% Sodium azide.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.