Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif . Mediates processing of TGFB1, an essential step in TGF-beta-1 activation . Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) . By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity). .; (Microbial infection) Cleaves and activates diphtheria toxin DT. .; (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA). .; (Microbial infection) Cleaves and activates HIV-1 virus Envelope glycoprotein gp160. .; (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. .; (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. .; (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells. .; (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F. .

p09958

Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE),FURIN FUR PACE PCSK3,FUR, PCSK3, PACE, FURIN, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, Furin

Human

ELISA

ELISA 1:5000-1:20000

87kD

Alpaca

Monoclonal

SA290

VHH-8His-Cys-tag

Purified by Nickel column.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.