MJJ428576

货号 规格 价格(¥)
MJJ428576S 50T
MJJ428576M 100T

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

ABMART实验方案下载

   蛋白质免疫共沉淀

   蛋白质印迹

   免疫荧光

   免疫组化

   膜再生

   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

直标流式抗体-Human pan-FZD Antibody(F252),FITC

Datasheet

Background

Description

Receptor for Wnt proteins . Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B . Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway . The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). .; (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. .

Uniprot

Q9UP38, Q14332, Q13467, O75084, Q9H461

Alternative Names

Frizzled-1 (Fz-1) (hFz1) (FzE1),FZD1,FzE1, Frizzled-1, hFz1, Fz-1, FZD1, Frizzled-2, FzE2, Fz-2, hFz2, FZD2, Frizzled-5, FzE5, C2orf31, hFz5, FZD5, Fz-5, Frizzled-7, hFz7, FzE3, Fz-7, FZD7, hFz8, Frizzled-8, Fz-8, FZD8

Specificity

Application Image

Reactivity

Human

Application

IF,ICC,FC,ELISA

Recommended Dilution

IF 1:100-1:500
ICC 1:100-1:400
FC 1:50-1:200
ELISA 1:5000-1:20000

Mol weight

72kD

Conjugation

FITC

Source

Mouse

Immunogen

Clonality

Monoclonal

Clone No.

F252

Isotype

IgG2a, kappa

Purification

Purity

Buffer

0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Concentration

0.5 mg/ml

Storage

Store at 4℃ for 12 months. Protect from light. Do not freeze.

Note

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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