Transcriptional coactivator for steroid receptors and nuclear receptors . Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter . Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis . Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism . Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program . Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner . Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). .

q9ubk2

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6),PPARGC1A LEM6 PGC1 PGC1A PPARGC1,LEM6, PGC1A, PPARGC1, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC1

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

92kD

Rabbit

Recombinant Human PPARGC1A (Ser636-Arg798).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.