As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins . It is strictly dependent on the extracellular presence of sodium . It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate . Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation . .; (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV) . The recognition for human SLC10A1/NTCP is highly specific . .

q14973

Hepatic sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (NTCP) (Solute carrier family 10 member 1) (SLC10A1),SLC10A1 NTCP GIG29,Cell growth-inhibiting gene 29 protein, Sodium/taurocholate cotransporting polypeptide, NTCP, SLC10A1, Sodium/bile acid cotransporter, Na(+)/taurocholate transport protein, Solute carrier family 10 member 1, Na(+)/bile acid cotransporter

Human

ELISA

ELISA 1:5000-1:20000

39kD

Alpaca

Monoclonal

SA311

VHH-8His-Cys-tag

Purified by Nickel column.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

0.78 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.