Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake . Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake . Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis . Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid . May contribute to the synthesis of sphingosine-1-phosphate . Does not activate C24 bile acids, cholate and chenodeoxycholate . In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol . However, it is not critical for THCA activation and bile synthesis in vivo . .; [Isoform 1]: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids . Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol . .; [Isoform 2]: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids. .

o14975

Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase),SLC27A2 ACSVL1 FACVL1 FATP2 VLACS,Long-chain fatty acid transport protein 2, Arachidonate--CoA ligase, 6.2.1.15, Fatty acid transport protein 2, FATP-2, Fatty-acid-coenzyme A ligase, very long-chain 1, Long-chain-fatty-acid--CoA ligase, 6.2.1.3, Phytanate--CoA ligase, 6.2.1.24, Solute carrier family 27 member 2, THCA-CoA ligase, 6.2.1.7, Very long-chain acyl-CoA synthetase, VLACS, VLCS, 6.2.1.-, Very long-chain-fatty-acid-CoA ligase, SLC27A2, ACSVL1, FACVL1, FATP2, VLACS

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

71kD

Rabbit

Recombinant Human SLC27A2 (Gly283-Leu620).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.