Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 . Catalyzes passive carrier mediated diffusion of iodide . Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane . May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract . Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines . May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons . Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) . Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced . .

q8n695

Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8),SLC5A8 AIT SMCT SMCT1,Apical iodide transporter, Sodium-coupled monocarboxylate transporter 1, SMCT1, AIT, Sodium iodide-related cotransporter, SMCT, Solute carrier family 5 member 8, Electrogenic sodium monocarboxylate cotransporter, SLC5A8

Human

ELISA

ELISA 1:5000-1:20000

67kD

Alpaca

Monoclonal

SA208

VHH-8His-Cys-tag

Purified by Nickel column.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.