Plays an essential role in the innate immune defense against viruses and bacteria . Promotes the ''Lys-48''-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication . Also plays a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP . Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways . Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation . Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression . Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). Also inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the ''Lys-63''-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation . .

q14142

Tripartite motif-containing protein 14,TRIM14 KIAA0129,KIAA0129, Tripartite motif-containing protein 14, TRIM14

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

50kD

Rabbit

Recombinant Human TRIM14 (Ser254-Pro442).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.