Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length . Directly binds the telomeric double-stranded 5''-TTAGGG-3'' repeat . Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres . Also acts as a transcription regulator that binds to promoter regions . Regulates expression of a small subset of genes, including MTFP1 . Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A . Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression . In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs . .

p10074

Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (hKR3) (Telomere zinc finger-associated protein) (TZAP) (Telomere-binding protein and transcriptional activator ZBTB48) (Zinc finger protein 855),ZBTB48 HKR3 TZAP ZNF855,Telomere zinc finger-associated protein, TZAP, Krueppel-related zinc finger protein 3, hKR3, Zinc finger and BTB domain-containing protein 48, Zinc finger protein 855, ZBTB48, HKR3, TZAP, ZNF855

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

78kD

Rabbit

Recombinant Human ZBTB48 (Val289-Leu628).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.