[Stable signal peptide]: Functions as a cleaved signal peptide that is retained as the third component of the GP complex (GP-C) . Helps to stabilize the spike complex in its native conformation . The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of G1 and G2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion . .; [Glycoprotein G1]: Forms the virion spikes together with glycoprotein G2 . The glycoprotein spike trimers are connected to the underlying matrix . Interacts with the host receptor. Mediates virus attachment to the host primary receptor alpha-dystroglycan DAG1 (alpha-DG) at the cell surface . This attachment induces virion internalization apparently through macropinocytosis (Probable) . Following endocytosis, there is a pH-dependent switch from binding DAG1 to the host lysosomal receptor LAMP1 . This latter binding triggers the dissociation of GP1, exposing the fusion subunit, GP2, such that fusion can occur . Down-modulates host DAG1 . .; [Glycoprotein G2]: Forms the virion spikes together with glycoprotein G1 . The glycoprotein spike trimers are connected to the underlying matrix . Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced by acidification . .

p08669

Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); Glycoprotein G1 (GP1); Glycoprotein G2 (GP2)],GPC GP-C,Pre-glycoprotein polyprotein GP complex, Pre-GP-C, Stable signal peptide, SSP, Glycoprotein G1, GP1, Glycoprotein G2, GP2, GPC, GP-C

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

56kD

Rabbit

Recombinant Lassa virus/LASV GPC (Gly260-Asp432).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.