Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides . Binds hemimethylated DNA as well . Recruits histone deacetylases and DNA methyltransferases to chromatin . Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Acts as a transcriptional repressor and plays a role in gene silencing . Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression . May enhance the activation of some unmethylated cAMP-responsive promoters . .
q9ubb5
Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2),MBD2,Methyl-CpG-binding domain protein 2, Methyl-CpG-binding protein MBD2, MBD2, DMTase, Demethylase
Human, Mouse, Rat
WB,IHC,ELISA
WB 1:500-1:2000IHC 1:50-1:300ELISA 1:5000-1:20000
44kD
Rabbit
Recombinant Human MBD2 (Glu145-Ala411).
Polyclonal
IgG
Purified by antigen affinity column.
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.
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