Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix . MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3) . Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways . Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes . While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a ''fight-or-flight'' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells . Participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake . Involved in antigen processing and presentation (By similarity). .

q8ne86

Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A),MCU C10orf42 CCDC109A,HsMCU,Calcium uniporter protein,mitochondrial,C10orf42,CCDC109A,Coiled-coil domain-containing protein 109A,MCU

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

40kD

Rabbit

Recombinant Human MCU (Val51-Thr233).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.