Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. .; Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways . Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury . In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF . Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation . Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents . Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia . .; [Regenerating islet-derived protein 3-gamma 16.5 kDa form]: Has bacteriostatic activity. .; [Regenerating islet-derived protein 3-gamma 15 kDa form]: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. .

o09049

Regenerating islet-derived protein 3-gamma (REG-3-gamma) (Pancreatitis-associated protein 3) (Regenerating islet-derived protein III-gamma) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein 3-gamma 15 kDa form],Reg3g Pap3,Regenerating islet-derived protein 3-gamma, Reg III-gamma, Pancreatitis-associated protein 1B, Regenerating islet-derived protein III-gamma, Pancreatitis-associated protein IB, REG III, REG-3-gamma, REG3G, PAP1B, PAP IB, PAP-1B

Mouse

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

20kD

Rabbit

Recombinant Mouse REG3G (Ser44-Ala174).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.