NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 . Can also catalyze to a smaller extent, the reduction of oxygen to superoxide . May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity . May regulate insulin signaling cascade . May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB . May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation . Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release . .; [Isoform 4]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . Involved in redox signaling in vascular cells . Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage . .; [Isoform 3]: Lacks superoxide-generating NADPH oxidase activity. .

q9nph5

NADPH oxidase 4 (EC 1.6.3.1) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase),NOX4 RENOX,RENOX,NOX4,Renal NAD(P)H-oxidase,NADPH oxidase 4,Kidney oxidase-1,Kidney superoxide-producing NADPH oxidase,KOX-1

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

67kD

Rabbit

Recombinant Human NOX4 (Gly210-Glu424).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.