Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response . Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2''-5''-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation . Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication . Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL . In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation . May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). .

p29728

2''-5''-oligoadenylate synthase 2 ((2-5'')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS),OAS2,p69 OAS / p71 OAS,OAS2,2-5A synthase 2,p69OAS / p71OAS,2''-5''-oligoadenylate synthase 2,(2-5'')oligo(A) synthase 2

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

83kD

Rabbit

Recombinant Human OAS2 (Val11-His346).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.