Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis . Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5''-PYGPYGGT-3'', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. .

q13950

Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit),RUNX2 AML3 CBFA1 OSF2 PEBP2A,AML3,OSF2,RUNX2,Core-binding factor subunit alpha-1,PEA2-alpha A,CBF-alpha-1,Osteoblast-specific transcription factor 2,Oncogene AML-3,CBFA1,Runt-related transcription factor 2,PEBP2A,OSF-2,SL3-3 enhancer factor 1 alpha A subunit,PEBP2-alpha A,Acute myeloid leukemia 3 protein,Polyomavirus enhancer-binding protein 2 alpha A subunit,SL3/AKV core-binding factor alpha A subunit

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

57kD

Rabbit

Recombinant Human RUNX2 (Val219-Val404).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.