Mediates the Na(+)-independent uptake of organic anions . Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3'',5''-triiodo-L-thyronine) . Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop . Involved in the clearance of endogenous and exogenous substrates from the liver . Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition . May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs . May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate . May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver . Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment . Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions . .

q9y6l6

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6),SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6,LST1,OATP1B1,OATP2,SLCO1B1,Solute carrier family 21 member 6,OATP-2,Sodium-independent organic anion-transporting polypeptide 2,LST-1,SLC21A6,OATP-C,OATPC,Solute carrier organic anion transporter family member 1B1,Liver-specific organic anion transporter 1

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

77kD

Rabbit

Recombinant Human SLCO1B1/LST-1/OATP-2 (Phe426-Phe537).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.