Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at ''Lys-4'' and ''Lys-9'' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis . Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at ''Lys-4'' and asymmetrically dimethylated at ''Arg-8'' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 . In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway . Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes . May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). .

q9y657

Spindlin-1 (Ovarian cancer-related protein) (Spindlin1),SPIN1 OCR SPIN,SPIN,SPIN1,Spindlin-1,Ovarian cancer-related protein,Spindlin1,OCR

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

30kD

Rabbit

Recombinant Human SPIN1 (Met1-Ser262).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.