Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking . Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation . Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination . Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length . Stimulates 26S proteasome activity . .

q9h2k2

Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein),TNKS2 PARP5B TANK2 TNKL,TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, Tankyrase-like protein, Poly [ADP-ribose] polymerase tankyrase-2, Tankyrase-related protein, TNKS2, Tankyrase II, ARTD6, Poly [ADP-ribose] polymerase 5B, Tankyrase-2, PARP5B, TNKL, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, TNKS-2, Protein poly-ADP-ribosyltransferase tankyrase-2

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

127kD

Rabbit

Recombinant Human TNKS2 (Ser959-Gly1166).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.